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Premature ejaculation (PE), despite its wide prevalence, is largely underdiagnosed and undertreated. Being a multifactorial dysfunction with strong cultural characteristics, PE requires skillful attitudes in the psychosexological support, necessary to manage the patient's and the couple's expectations, as well as in the medical treatment. Dapoxetine is a short‐acting selective serotonin reuptake...
Background
Cryptorchidism is one of the most common congenital disorders in boys and it is associated with a higher risk of sub‐fertility and testicular cancer. Testicular descent occurs during embryo‐fetal development in two phases, transabdominal and inguino‐scrotal. In the latter process, androgens play a leading role. The androgen receptor has in its N‐terminal domain, two aminoacidic repeats...
Background
An important issue for young men affected by testicular germ cell tumor (TGCT) is how TGCT and its treatment will affect, transiently or permanently, their future reproductive health. Previous studies have reported that xenobiotics can induce changes on human sperm epigenome and have the potential to promote epigenetic alterations in the offspring.
Objectives
Here, we report the first...
Background
A growing number of centers worldwide are preserving testicular tissue (TT) of young boys at risk of fertility loss to preserve their fertility. Data in this regard are scarce and experience sharing is essential to the optimization of the process.
Objectives
This report of our 10‐year activity of pediatric fertility preservation (FP) has the objective to (1) improve knowledge regarding...
Background
Low testosterone (T) levels in men associate with increased risks of obesity, type 2 diabetes, metabolic syndrome, and cardiovascular diseases. However, most studies are cross‐sectional with follow‐up‐time < 10 years, and data on early growth are limited.
Objective
To compare prenatal factors and body mass index (BMI) development from birth to age 46 in relation to low T at age 31...
Objective
To determine the most financially optimal surgical approach for testicular sperm retrieval for men with non‐obstructive azoospermia.
Design
A decision tree was created examining five potential surgical approaches for men with non‐obstructive azoospermia pursuing one cycle of intracytoplasmic sperm injection. An expected financial net loss was determined for each surgical option based...
Background
Decision‐making regarding varicocele management can be a complex process for patients and families. However, to date, no studies have presented ways to mitigate the decisional conflict surrounding varicoceles.
Objective
To facilitate a discussion among physicians in order to develop a framework of the decision‐making process regarding adolescent varicocele management, which will inform...
Background
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) may affect the male reproductive system as it uses angiotensin‐converting enzyme (ACE)2, which is expressed in testicular tissue, as an entry point into the cell. Few studies have evaluated the long‐term effects of mild coronavirus disease 2019 (COVID‐19) on testicular function, and insulin‐like factor 3 (INSL3) levels have not...
Background
The concerning trend on male infertility global prevalence, together with the unexplainable causes in half of those cases, highlights that there are still aspects of this disease to be understood and solved. To address this issue, one should not only be aware of the limitations of the implemented diagnostic tools, but also understand the sperm cell in depth, structurally, biochemically,...
Background
Obesity‐induced hypogonadism, which manifests as erectile dysfunction and a lack of libido, is a less visible and under‐recognized obesity‐related disorder in men.
Objective
We examined the impact of weight loss on total (TT) and free testosterone (FT) levels, and constructed nomograms to provide an easy‐to‐use visual aid for clinicians.
Materials and methods
Meta‐analysis was conducted...
Background
Multiple morphological abnormalities of sperm flagella is an idiopathic asthenoteratozoospermia characterized by absent, short, coiled, angulation, and irregular‐caliber flagella. Genetic variants of DNAH1 gene have been identified as a causative factor of multiple morphological abnormalities of sperm flagella and intracytoplasmic sperm injection is an available strategy for infertile...
Background
The ubiquitin ligase HECT, UBA, and WWE domain‐containing E3 ubiquitin protein ligase 1 is essential for the establishment and maintenance of spermatogonia. However, the role of HECT, UBA, and WWE domain‐containing E3 ubiquitin protein ligase 1 in regulating germ cell differentiation remains unclear, and clinical evidence linking HECT, UBA, and WWE domain‐containing E3 ubiquitin protein...
Background
Telomeres are essential for the integrity of chromosome ends during cell division and their involvement in different processes linked to aging has been established. These chromosome components are involved in spermatogenesis and seem to play an important role in fertilization and embryo development. Telomere length is shortened with each cell division. Recently, short sperm telomere length...
Background
Equine spermatozoa appear to differ from spermatozoa of other species in using oxidative phosphorylation preferentially over glycolysis. However, there is little information regarding effects of different energy sources on measured parameters in equine spermatozoa.
Objective
To determine the effect of three individual energy substrates, glucose, pyruvate, and lactate, on motion characteristics,...
Background
Selective oestrogen receptor modulators and aromatase inhibitors stimulate endogenous gonadotrophins and testosterone in men with hypogonadism. There are no systematic reviews/meta‐analyses assessing the effects of selective oestrogen receptor modulators/aromatase inhibitors on semen parameters in men with secondary hypogonadism.
Objectives
To assess the effect of monotherapy or a combination...
Background
The odds of erectile dysfunction are three times more prevalent in diabetes. Severe peripheral vascular and neural damage in diabetic patients responds poorly to phosphodiesterase‐5 (PDE5) inhibitors. However, bone morphogenetic protein 2 is known to be involved in angiogenesis.
Objectives
To assess the efficacy of bone morphogenetic protein 2 in stimulating angiogenesis and augmenting...
Background
To‐date there have been minimal studies to investigate an association between the gut microbiome and erectile dysfunction. There have been many inflammatory diseases linked to gut microbiome dysbiosis; such as cardiovascular disease and metabolic syndrome. These same inflammatory diseases have been heavily linked to erectile dysfunction. Given the correlations between both conditions and...
Background
Banking of frozen spermatozoa by single men opens the possibility of procreation long after their death. Requests for posthumous reproduction by the families of the deceased are growing, raising an ethical debate, especially when written instructions were not left by the patients and in cases of unplanned perimortem collection. The issue of the progenitors' intention to procreate after...
Background
Sleep, particularly rapid eye movement sleep, has been found to be associated with sleep‐related erections. While RigiScan is currently a more accurate method for monitoring nocturnal erectile events, the Fitbit, a smart wearable device, shows great potential for sleep monitoring.
Objectives
To analyze the relationship between sleep‐related erections and sleep by recruiting sexually...
Background
General obesity classified by body mass index has been linked to a reduction in semen quality; however, evidence on the adverse effect of central obesity on semen quality remains limited.
Objectives
To investigate the association between central obesity and semen quality.
Materials and methods
We conducted a cross‐sectional study of 4513 sperm donation volunteers in Guangdong Provincial...
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